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pentobarbital will minimize the extent or influence of midostaurin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Sturdy CYP3A4 inducers may lessen midostaurin concentrations causing lowered efficacy.​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​â€